A well-implemented version of Civ (preferably Civ IV) with a solid asynchronous multiplayer implementation has been my greatest gaming dream since I first played UniWar, and realized just what a revolution and paradigm shift asynchronous gaming really is. Civ, with its long-term focused and contemplative gameplay, might just be the perfect async title.
This version looks really good. Though I can just imagine it being released for iOS, in all its splendor, but without any kind of multiplayer, little less asynchronous multiplayer
Vocalist of Neverlast
Game Center/OpenFeint/Plus+/[insert arbitrary game network, online character or multiplayer account here]: Ayjona